Please note: This is a Single Viewer eCast registration for one participant for this eCast for both the live and on-demand version of this eCast. If you are interested in presenting this program to a group, please see the “eCast Registration Form– Group Viewing” form on the eCast program page.

Access instructions for the live eCast will be provided via email approximately 2-3 business days prior to the live program date. Access instructions for the on-demand version of this program will be provided via email approximately 7-10 business days after the live program has occurred and the on-demand version is available. If registering after the on-demand version is available, immediate access is granted via the AABB Education Website at https://education.aabb.org.

Program Description: Hematopoietic stem cells are self renewing, multipotent cells with malignancies of these cells being fatal and their replacement with normal stem cells is often required to cure disease.  Human Leukocyte antigens (HLA) antigens are histocompatibility antigens and disparity in HLA antigens between stem cell transplant donor and recipients is one of the most important factors influencing transplant outcomes such as relapse, graft failure and graft vs host disease. Donor selection criteria including HLA matching, sensitization to HLA in selecting mismatch and role of non-HLA components in selection process for stem cell transplants will be discussed. Concept of “permissive mismatch” will be covered as well.  This program will review the available approaches, and the benefits and limitations of each of the post-transplant monitoring methodologies the HLA labs utilize to measure donor engraftment.