On-Demand version of the June 5, 2019 eCast.
Please note: This is a Single Viewer On-Demand eCast available for one registrant to access the on-demand version of the eCast. Once registered, access is granted via the AABB Education Website located at https://education.aabb.org.
Program Description: Four-Factor Prothrombin Complex Concentrate is used for reversal of vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) in the setting of major hemorrhage or urgent need for surgery. This program will describe the efficacy and safety of Four-Factor Prothrombin Complex Concentrate compared to plasma for VKA reversal prior to urgent surgical or invasive procedures. Practical considerations such as fixed versus weight-based dosing will also be explored. Direct oral anticoagulants (DOACs) are replacing VKA because of better safety profile and no need for routine testing. However, bleeding is still a serious complication of DOACs. The second part will discuss management of DOACs related bleeds and specific antidotes and non-specific agents.